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HEK293/Human Tau-K18 (GFP) Stable Cell Line

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产品详情

    1. Genetically modified cell lines best reflect MOA (Mechanism of Action)
    2. Higher activity and larger assay window for robust and reproducible cell-based bioassay
    3. Comprehensive application data to support assay development and validation
    4. Full tracible record, stringent quality control and validated cell passage stability
    5. Parental cell line legally obtained from internationally recognized cell resource bank and commercially licensed
    6. Global commercial license assistance whenever regulatory filing is required

  • 描述（Description）

    HEK293/Human Tau-K18 (GFP) Stable Cell Line

  • 应用说明（Application）

    • Tau PFF induced intracellular aggregation assay

  • 生长特性（Growth Properties）

    Adherent

  • 筛选标记（Selection Marker）

    Hygromycin B (250 μg/mL)

  • 培养基（Complete Growth Medium）

    DMEM medium + 10% FBS

  • 冻存液（Freeze Medium）

    10% DMSO + 90% FBS

  • 装量（Quantity）

    1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium

  • 存储（Storage）

    Frozen in liquid nitrogen.

  • 支原体检测（Mycoplasma Testing）

    Negative

  • 无菌检测（Sterility Testing）

    Negative

  • 使用说明（Instructions for Use）

    See data sheet for detailed culturing and assay protocol.

产品展示

  • Receptor Assay

    Tau FACS

    FACS analysis of Tau-K18 (GFP) on HEK293/Human Tau-K18 (GFP) Stable Cell Line.
    HEK293/Human Tau-K18 (GFP) Stable Cell Line was red line, negative control HEK293 cells was grey line (QC tested).

    Protocol

  • 活性（Bioactivity）-CELL BASE

    Tau CELL

    HEK293/Human Tau-K18 (GFP) Stable Cell Line (Cat. No. CHEK-ATP087) were transduced with Human Tau-441 Pre-formed Fibrils, Tag Free (Cat. No. TAU-H5115) and Human Tau-441, Tag Free (Cat. No. TAU-H5117) respectively. The fluorescence of GFP-Tau (Green) and DAPI (Blue) were detected by confocal microscope. A. Lipo2000 transduction. B. Lipo2000 and Human Tau-441, Tag Free transduction. C. Lipo2000 and Human Tau-441 Pre-formed Fibrils, Tag Free transduction. Scale bars, 50 μm (Routinely tested).

    Protocol
*如有相关细胞池需求请联系我们

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背景介绍

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

前沿进展

 
药物研发进展
  • 英文全称：

    Microtubule-associated protein tau

  • 中文全称：

    微管相关蛋白tau

  • 种类：

  • 上市药物数量：

    1 详情

  • 临床药物数量：

    38 详情

  • 最高研发阶段：

    临床三期

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