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Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free

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  • 分子别名（Synonym）

    DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

  • 表达区间及表达系统（Source）

    Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free (TAU-H5113) is expressed from E. coli cells. It contains AA Gln 244 - Glu 372 (Accession # P10636-8 (P301L)).

    Predicted N-terminus: Met

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    Tau Structure

    This protein carries no "tag".

    The protein has a calculated MW of 13.8 kDa.

  • 偶联（Conjugate）

    Unconjugated

  • 应用说明（Application）

    THT, cell assay, drug screening and other in vitro experiment.

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    95% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in PBS, pH7.4.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C;
    2. The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions;
    3. The sonicated fibril should be stored at -70°C for not more than 8 weeks.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    Tau SDS-PAGE

    Tau-441 K18 (P301L) monomer on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • 电镜（Electron Microscope）

    Tau ELECTRON MICROSCOPE

    Transmission electron microscopy (TEM) of Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free (Cat. No. TAU-H5113). Fibril structure is visible on negative stain TEM images of TAU-H5113 (Routinely tested).

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背景介绍

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

前沿进展

 
药物研发进展
  • 英文全称：

    Microtubule-associated protein tau

  • 中文全称：

    微管相关蛋白tau

  • 种类：

  • 上市药物数量：

    1 详情

  • 临床药物数量：

    38 详情

  • 最高研发阶段：

    临床三期

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